Reduce appetite (except for fenfluramine) -Reduction their effect.Cautions
When taken periciazine recommended regular monitoring of peripheral blood, especially in the case of fever or infection joining (the possibility of development of leukopenia trenbolone acetate buy and agranulocytosis). In the event of significant changes in the peripheral blood (leukocytosis, granulocytopenia) treatment periciazine should be discontinued.
Neuroleptic malignant syndrome – in the case of unexplained fever treatment periciazine should be discontinued, since it can be a manifestation of neuroleptic malignant syndrome, early manifestations of which may also have the appearance of vegetative disorders (such as excessive sweating, unstable heart rate and blood pressure).
during the treatment should not take alcohol and alcohol-containing products, as this potentiation of sedation leads to a reduction reaction, which can be dangerous for people who manage the transport means and mechanisms (see. section “Interactions with other medicinal products”)
Due to the ability of the drug to reduce the seizure threshold, while taking periciazine patients with epilepsy after them should be careful clinical and, whenever possible, electroencephalographic monitoring.
except in special cases, periciazine not should be used in patients with Parkinson’s disease (see. sections “Contraindications”, subsection “Precautions”).
Antipsychotics group phenothiazine derivatives are capable of dose-dependently lengthen the QT interval, which, as we know, can increase the risk of serious ventricular arrhythmias, including life-threatening bidirectional ventricular tachycardia type “pirouette”. The risk of their occurrence increases with the presence of bradycardia, hypokalemia, and prolongation of the QT interval (congenital or acquired under the influence of drugs, increasing the duration of the QT interval). Before the appointment of neuroleptic therapy, permitting the patient’s condition, it is necessary to exclude the presence of factors predisposing to the development of severe arrhythmias (bradycardia less than 55 beats per minute, hypokalemia, hypomagnesemia, slowing intraventricular conduction and congenital long QT or a long QT interval, the use of other drugs, prolonging the interval QT) (see. sections “Contraindications”, subsection “wary” “Side effects”).
The control of these risk factors should be performed during treatment with the drug.
in case of occurrence in patients receiving periciazine bloating and abdominal pain should carry out the necessary tests in order to exclude bowel obstruction, trenbolone acetate buy since the development of this side effect requires the necessary urgent measures.
particularly close monitoring of patients’ condition and compliance with special care is required when assigning periciazine and other antipsychotic drugs in elderly patients, patients with cardiovascular disease , to patients with hepatic and renal failure, in elderly patients with dementia and patients having risk factors for stroke (see. See section “Contraindications”, subsection “Precautions”).
In a randomized clinical trial, compared several atypical antipsychotics to placebo conducted in elderly patients with dementia, there was a threefold increase in the risk of cerebrovascular events. The mechanism of this risk is not known. We can not exclude an increase in such risk when taking other antipsychotics or other patient populations, so periciazine should be used with caution in patients with risk factors for stroke.
In elderly patients with psychosis associated with dementia, for the treatment of antipsychotic drugs was observed increase in the risk of death.
Although the causes of death in clinical trials with atypical antipsychotics were varied, most of the causes of deaths were either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that, similar to the treatment of atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which an increase in mortality may be due to antipsychotic, not some features of the patients is not clear.
In the application of antipsychotic drugs have been cases of venous thromboembolism, sometimes fatal. Therefore, you should periciazine used with caution in patients with risk factors for patients developing thromboembolic events, see “Side effects”.
In connection with the possibility of withdrawal at the abrupt cessation of treatment with high doses of periciazine (see. Section “Side Effects”), the abolition of the drug when it is used in high doses should be carried out gradually.
in connection with the development of photosensitivity, patients receiving periciazine should be advised to avoid exposure to direct sunlight.
due to the fact that people are often called phenothiazines, in very rare cases may develop contact sensitization of skin to phenothiazines, should avoid direct contact with skin.
In pediatric patients it is advisable to use Neuleptil ® 4% solution for oral administration.
Effects on ability to drive vehicles or other mechanisms
should inform patients, especially those who are the drivers of vehicles or persons working with other mechanisms, of the possibility of their sleepiness and decrease reaction in connection with the drug intake, especially at the trenbolone acetate buy beginning of treatment, as a violation of psychomotor reactions can be potentially dangerous when driving and operating machinery.