Trenbolone acetate 100mg – a drug that improves myocardial metabolism and muscle tissue. On chemical structure similar to endogenous energy-rich phosphocreatine. It stops the process of destruction of the sarcolemma of cardiomyocytes and ischemic myocytes, provides energy intracellular transport. By improving microcirculation drug reduces the size of necrosis and ischemia. When ischemia and post-ischemic reperfusion has antiarrhythmic effect, which is associated with a decrease in ventricular ectopic activity and the preservation of the physiological functions of the cells of Purkinje fibers.
Distribution – If a single on / in infusion the maximum concentration of drug in the blood plasma is determined na1-3 minutes. The greatest amount of drug accumulated in the skeletal muscles, myocardium and brain. . In the tissues of the liver and the lungs accumulation of minor drug
Excretion – The half-life in the fast phase is 30-35 minutes; The half-life in the slow phase of several hours. Excreted by the kidneys.
Indications for use
in combination therapy:
- acute myocardial infarction;
- chronic heart failure;
- intraoperative trenbolone acetate 100mg myocardial ischemia;
- intraoperative limb ischemia;
- acute stroke;
- in sports medicine: syndrome for the prevention of physical overexertion and improve adaptation to extreme physical stress.
- Hypersensitivity to the drug.
Pregnancy and lactation
Safety Data and effectiveness of the drug Neoton during pregnancy and lactation (breastfeeding) is not available.
The drug should be administered as soon as possible after signs of symptoms of ischemia, which provides a more favorable prognosis of the disease. Neoton not apply to emergency correction of cardiac activity.
Dosage and administration In acute myocardial infarction in the 1st day administered in 2-4 g / bolus infusion followed by dropping 8-16 g per 200 ml of 5% glucose solution for 2 hours in 2nd day:. 2 -4 g / drip 2 times / day. The 3rd day: 2 g / drip 2 times / day. If necessary, the drug infusion rate of 2 g of 2 times / day can be carried out within 6 days. In chronic heart failure is introduced into / in the drip for 1-2g 2 times / day for 10-14days. When intraoperative myocardial ischemia drug is administered as a part of a conventional cardioplegic solution in an amount of 3 g per 1 liter. Neoton solution is added to the composition immediately prior to administration. It is recommended a course of the drug infusion, 2 g 2 times / day for 3-5 days prior to surgery and for 1-2 days after surgery. If possible, the development of intraoperative limb ischemia is recommended / jet enter 2-4 g of the drug prior to surgery followed by infusion of 8-10 g 5% glucose solution during the operation and the period of reperfusion.
Hypersensitivity to the drug, hypotension (with the rapid on / in the introduction).
Interaction with other medicinal products
When used in the trenbolone acetate 100mg complex therapy Neoton enhances the effectiveness of antiarrhythmic; antianginal drugs, and drugs that have a positive inotropic effect on myocardial function.
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