Very rarely:. Development of withdrawal symptoms when a dramatic treatment with high doses of periciazine manifested by nausea, vomiting, insomnia, and the trenbolone acetate side effects possibility of worsening of the underlying disease or the development of extrapyramidal disorders among patients treated with neuroleptics phenothiazine series, were marked by isolated cases of sudden death, possibly caused by cardiac causes , as well as cases of unexplained sudden death.
Overdose Symptoms Symptoms phenothiazines overdose include CNS depression, progressing from drowsiness to coma with areflexia. In patients with early signs of intoxication or intoxication of average weight can be observed anxiety, confusion, agitation, excited or derilioznoe state. Other overdose manifestations may include decreased blood pressure, tachycardia, ventricular arrhythmias, ECG changes, collapse, hypothermia, miosis, tremors, muscle twitching, a spasm or muscle stiffness, cramps, dystonic movements, muscular hypotonia, difficulty swallowing, respiratory depression, apnea, cyanosis. It is also possible occurrence of polyuria, leading to dehydration and severe extrapyramidal dyskinesia. Treatment Treatment should be symptomatic and carried out in a specialist unit, where it is possible to organize the monitoring of respiratory function and cardiovascular system and keep it up to complete elimination of overdose phenomena. If, after taking the drug passed less than 6 hours, it is necessary to gastric lavage and aspiration of its contents. The use of emetics are contraindicated because of the risk of aspiration of vomit on the background of lethargy and / or extrapyramidal disorders.
Perhaps the use of activated carbon. No specific antidote. Treatment should be directed at maintaining vital functions of the body. By reducing the patient’s blood pressure must be set in the horizontal position with raised legs. Displaying infusion intravenous fluids. In the case where liquid introduction is not sufficient to eliminate hypotension may administering norepinephrine, dopamine or phenylephrine. Introduction of epinephrine is contraindicated. When hypothermia is possible to wait for her self-authorization, except in cases when the body temperature drops to a level that may develop cardiac arrhythmias (ie up to 29.4 ° C). Ventricular or supraventricular tachyarrhythmias usually respond to restoration of normal temperature and removing the body of hemodynamic and metabolic disorders. When you save a life-threatening arrhythmias may require administration of antiarrhythmic drugs. Avoid the use of lidocaine and, if possible, a long-acting anti-arrhythmic agents. When oppression CNS and respiratory depression may require Diverting patients on mechanical ventilation and an antibiotic for prevention of pulmonary infections. Severe dystonic reactions usually respond to intramuscular or intravenous protsiklidina (5-10 mg) or orphenadrine (20-40 mg). Convulsions may improve intravenous administration of diazepam. When extrapyramidal disorders intramuscular used anticholinergic antiparkinsonian agent.
Interaction with other medicinal products
- Since dopaminergic agonists (levodopa, amantadine, apomorphine, bromocriptine, cabergoline, entacapone, lisuride, pergolide, piribedil, pramipexole, quinagolide, ropinirole) in patients with Parkinson’s disease is the mutual antagonism between dopaminergic agonists and periciazine. Dopaminergic agonists may enhance psychotic disorders. If patients with Parkinson’s disease receiving dopaminergic agonists requires neuroleptic treatment, then they should spend their abolition by gradual dose reduction (sudden cancellation of dopaminergic agonists may increase the risk of neuroleptic malignant syndrome). When used in conjunction with drug periciazine levodopa should use the minimum effective dose of both drugs.
- With alcohol – potentiation trenbolone acetate side effects of sedation caused periciazine.
- With amphetamine, clonidine, guanethidine – the effect of these drugs is reduced when taken with neuroleptics.
- With sultopride -. Increased risk of ventricular arrhythmias, particularly ventricular fibrillation, drug combination, the application of which requires careful observance
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